On average in the United States, a person dies every 7 minutes from a drug overdose; also, a baby is born dependent (not addicted) on opioids every 30 minutes. These staggering statistics involving human heartbeats silenced involve illicit substances of abuse rather than legally prescribed and dispensed opioid medications. Headlines in the US and globally decry the “Opioid Crisis,” “Opioid Epidemic,” or what may perhaps be better termed the “Opioid Pandemic,” but do we as healthcare professionals have a firm understanding of what is going on? One may ask, “Just how did we get this far in the opioid crisis?” or “What pain management treatment options do my patients have besides prescription opioid medications?” or even “How do I help patients I have inherited from other healthcare professionals?” Healthcare professionals are part of the overall supply chain of each and every prescription medication, even if the concerning risks arise once the products are transferred to another person outside of any healthcare relationship. Amongst all this opioid madness, healthcare professionals, and the rest of society, need to progress by utilizing best practices in pain management to ensure safe and efficacious pain treatment to the highest degree possible. Sounds like the perfect time to review best practices in pain management. When? Now. And always.