Scratching the Surface of BTK Inhibition for Chronic Spontaneous Urticaria: Beyond Skin Deep

BTK inhibitors have demonstrated great promise for addressing various treatment challenges for chronic urticaria patients by improving symptom control and more effective targeting of disease pathways. To capitalize on the potential treatment benefits of BTK inhibitors, clinicians require expert guidance on the classifications of chronic urticaria to more accurately diagnose CSU, the role of the BTK pathway and the mechanism of BTK inhibitors, clinical data for current and emerging therapies, as well as current treatment gaps and how emerging BTK inhibitors may address common treatment challenges. Led by the foremost experts in treating CSU, this 1-hour educational activity will address the specific pathophysiology of CSU and the BTK pathway, the mechanism of BTK inhibition in CSU disease management, clinical data regarding BTK inhibitors currently being investigated, and the impact of these agents on clinical practice.

Target Audience

This activity is designed for an audience of dermatology and allergy specialists, including physicians, nurses, and other advanced practice providers (nurse practitioners/physician assistants) who may treat CSU.

Learning Objectives

Upon completion of the educational activity, participants should be better able to:

  • Describe the pathogenesis of CSU and the role of the BTK pathway in the disease
  • Describe the underlying mechanism of action of BTK inhibitors being investigated for treatment of CSU
  • Evaluate current treatment gaps and how emerging BTK inhibitors may address treatment challenges in chronic urticaria.
Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 ANCC
  • 1.00 Participation
Course opens: 
12/16/2024
Course expires: 
12/15/2025
Rating: 
0
  • Clinical Presentation, Symptomology, and Diagnosis
  • Mechanisms of Disease
  • Current Treatment Strategies and Emerging Therapies
  • Treatment Gaps and Challenges
  • BTKi Mechanism of Action

Jennifer L. Hsiao, MD
Associate Professor of Clinical Dermatology
University of Southern California
Los Angeles, CA

Jason E. Hawkes, MD MS FAAD
Investigator
Oregon Medical Research Center
Portland, OR

‘This activity is provided by AKH Inc., Advancing Knowledge in Healthcare and Tarsus Cardio dba LiVDerm.’

In support of improving patient care, this activity has been planned and implemented by AKH Inc., Advancing Knowledge in Healthcare and Tarsus Cardio dba LiVDerm. AKH Inc., Advancing Knowledge in Healthcare is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physicians

AKH Inc., Advancing Knowledge in Healthcare designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses

1 ANCC contact hours.

NP's and PA's may be able to utilize one of the credits provided on this activity.

Commercial Support

This activity is supported by an independent medical education grant from Novartis Pharmaceuticals Corporation.

DISCLOSURES

Name

Relationship

Commercial Interest

Jennifer L. Hsiao, MD

 

Advisor

Abbvie, Aclaris, Boehringer Ingelheim, Incyte, Novartis, Sanofi, UCB

Researcher (Investigator)

Amgen, Boehringer Ingelheim, Incyte

Speaker

AbbVie, Galderma, Novartis, Sanofi Regeneron,  UCB

Jason Hawkes, MD

Advisor

AbbVie, Apogee, Arcutis, BI, Blueprint Medicines, BMS, Boxer Capital LLC, Cogent Biosciences, Dermavant, Galderma, Institute for Systems Biology (ISB), Janssen, LEO, Novartis, Regeneron, Sanofi, Sun Pharma, Takeda, and UCB

Consultant

AbbVie, Acelyrin, Alumis, Amgen, Apogee Therapeutics, CellDex, Concert Pharmaceuticals, Incyte, Janssen, LEO, Lilly, Novartis, Sanofi, Sun Pharma, and Takeda

Speaker

BMS, BI, Galderma, Regeneron, Sanofi, and UCB

Dorothy Caputo, MA, BSN, RN, VP, Healthcare CE and Operations

N/A

Nothing to disclose

Bernadette Makar, MSN, APRN-BC, NP-C (planner/reviewer)

N/A

Nothing to disclose

Michele Bielarski, RN (planner/reviewer)

N/A

Nothing to disclose

AKH Inc Staff and Planners

N/A

Nothing to disclose

Tarsus dba LiVDerm Staff and Planners

N/A

Nothing to disclose

Disclosure

It is the policy of AKH Inc. to ensure independence, balance, objectivity, scientific rigor, and integrity in all of its continuing education activities. The author must disclose to the participants any significant relationships with ineligible companies whose products or devices may be mentioned in the activity or with the commercial supporter of this continuing education activity. Identified conflicts of interest are mitigated by AKH prior to accreditation of the activity. AKH planners and reviewers have no relevant financial relationships to disclose.

Refer to Disclosure table in the attached front matter.
Disclaimer

This course is designed solely to provide the healthcare professional with information to assist in his/her practice and professional development and is not to be considered a diagnostic tool to replace professional advice or treatment. The course serves as a general guide to the healthcare professional, and therefore, cannot be considered as giving legal, nursing, medical, or other professional advice in specific cases. AKH Inc. specifically disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through participant's misunderstanding of the content.

Disclosure of Unlabeled Use and Investigational Product

This educational activity may include discussion of uses of agents that are investigational and/or unapproved by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

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Available Credit

  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 ANCC
  • 1.00 Participation
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Required Hardware/software

A computer with an internet connection

Internet Browser: Internet Explorer 7.x or higher, Firefox 4.x or higher, Safari 2.x or higher, or any other W3C standards compliant browser

Other additional software may be required such as PowerPoint or Adobe Acrobat Reader.