Advanced Cutaneous Squamous Cell Carcinoma in the Era of Systemic Immunotherapy: Implications for Risk Stratification and Treatment

Target Audience

This activity is designed to meet the needs U.S. based dermatologists, oncologists, nurse practitioners, nurses, and pharmacists who are involved in the care and treatment of patients with cutaneous squamous cell carcinoma.

Learning Objectives

  • Describe commonly-used systems and approaches for cSCC risk stratification and staging
  • Identify high-risk patients with cSCC based on the latest staging systems, risk factors, and guidelines
  • Summarize the mechanism of action, rationale, and efficacy of PD-1 inhibitors in advanced cSCC
  • Develop individualized treatment regimens for patients with advanced cSCC that is not amendable to surgery, radiation therapy, or chemotherapy
Course summary
Available credit: 
  • 1.00 ACPE Pharmacy
  • 1.00 AMA PRA Category 1 Credit
  • 1.00 ANCC
  • 1.00 Participation
Course opens: 
Course expires: 

Webcast I.  Identifying high-risk cSCC 

  • Epidemiology and cSCC burden
  • Diagnostic evaluation
  • High-risk csCC
    • Risk factors
    • Overview of staging and risk stratification
  • Patient Cases
  • Expert Perspectives

Webcast II.  The role of PD-1 inhibitors in advanced cSCC

  • Rationale for using PD-1 inhibitors in cSCC
  • Efficacy and safety of PD-1 inhibitors
    • Cemiplimab, pembrolizumab, nivolumab
  • Selecting patient candidates for immunotherapy
  • Patient Cases
  • Expert Perspectives

Chrysalyne D. Schmults, MD

Vice Chair, Surgical Oncology, Department of Dermatology; Director, Mohs and Dermatologic Surgery Center; Program Director, Micrographic Surgery and Dermatologic Oncology Fellowship Program; Associate Professor, Harvard Medical School

Abigail Waldman, MD

Clinical Director, Mohs and Dermatologic Surgery CenterDirector, Mohs Surgery, VA Boston Healthcare System; Assistant Professor, Harvard Medical School; 

Emily Ruiz, MD, MPH  

Associate Physician at the Mohs and Dermatologic Surgery Center at Brigham and Women’s Faulkner Hospital, Assistant Professor in Dermatology at Harvard Medical School and Director of the High-Risk Skin Cancer Clinic at Dana Farber/Brigham and Women’s Hospital.

Todd E. Schlesinger, MD, FAAD, FASMS

Medical Director, Board-Certified Dermatologist, Fellow, American Society for Mohs Surgery


Credit provided by AKH Inc., Advancing Knowledge in Healthcare


In support of improving patient care, this activity hs been planned and implemented by AKH Inc., Advancing Knowledge in Healthcare and Tarsus Cardio dba LiVDerm. AKH Inc., Advancing Knowledge in Healthcare is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurse Credentialing Center (ANCC), to provide continuing education for the healthcare team. 



AKH Inc., Advancing Knowledge in Healthcare designates this enduring material activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


1 ANCC contact hour 


AKH Inc., Advancing Knowledge in Healthcare designates this continuing education activity for 1 contact hour.

Commercial Support

This activity is supported by an educational grant from Merck Sharp & Dohme Corp.


It is the policy of AKH Inc. to ensure independence, balance, objectivity, scientific rigor, and integrity in all of its continuing education activities. The author must disclose to the participants any significant relationships with ineligible companies whose products or devices may be mentioned in the activity or with the commercial supporter of this continuing education activity. Identified conflicts of interest are mitigated by AKH prior to accreditation of the activity. AKH planners and reviewers have no relevant financial relationships to disclose.





Chrysalyne D. Schmults


Skin Cancer Outcomes Consortium (SCOUT), The National Comprehensive Cancer Network (NCCN)


Regeneron Pharmaceuticals, Sanofi; has received

Contracted Research

Castle Biosciences, Regeneron Pharmaceuticals, Novartis, Genentech, and Merck

Steering Committee Member

Castle Biosciences, Regeneron Pharmaceuticals

Emily Ruiz, MD MPH


Genentech, Regeneron/Sanofi

Contracted Research

Merck, Regeneron

Todd Schlesinger, MD

Advisory Board

Allergan, Almirall (Honoraria), Amgen, Bioderma (Honoraria), Biofrontera AG (Honoraria), Celgene, Greenway Therapeutix (No Compensation Received), Remedly, Inc (Stock Options), Suneva Medical, Inc (Honoraria)


AbbVie (Honoraria), Aclaris (Honoraria), Allergan, (Honoraria), Almirall, BioFrontera, Bristol-Meyers Squibb (Honoraria), Castle Biosciences, Eli Lilly (Fees), Evolus Foundation for Research and Education in Dermatology (Fred), EPI Health (Honoraria), Galderma (Honoraria), Kintor, LEO Pharmaceuticals, Lilly (USA), MED Learning Group CME Program (August-October 2019), Merz (Honoraria), MJH Associates ONCLive SCC Filming (Stacy Jaffe), Nextphase, Novartis (Honoraria), Ortho Dermatologics, Pfizer, Prolacta Bioscience, Regeneron (Fees), Sisaf, Sun Pharma, Suneve Medical, UCB, Verrica

Contracted Research

AbbVie, Aclaris Arcutis Premier Research, Arcutis Biotherapeutics, Akros, Allergan, Astellas Pharma US, Inc, AOBiome Therapeutics, Bioderma, Biofrontera, BioPharmx, Boehringer Ingerlheim, Bristol-Meyers Squibb, Cara Therapeutics, Castle BioScience, Celgene, Centocor Ortho Biotech, Inc, ChemoCentryx, Coherus Biosciences, Corrona, Dermavant, Dermira, DT Pharmacy & DT Collagen (Melasma), Eli Lilly, Galderma (Nestle), Genentech, Inc, Janssen Pharmaceuticals, Inc, Kinex, Kiniksa, Leo, Merz, Novartis, Pfizer, Regeneron Sanofi, Sisaf Tetra Derm Group, LLC (Wound Healing), Trevi

Speakers Bureau

Aclaris, Almirall, Dermira (Honoraria), DUSA, EPI Health, Regeneron (Honoraria), Regeneron and Sanofi Aventis, Sanofi Genzyme, Sun Pharma (Honoraria), Suneva (Honoraria)

Abigail Waldman, MD


Nothing to disclose

Dorothy Caputo, MA, BSN, RN - CE Director of Accreditations


Nothing to disclose

Dorothy A. Duffy, RPh


Nothing to disclose

LiVDerm Planners and Reviewers


Nothing to disclose

AKH Planners and Reviewers


Nothing to disclose

All of the relevant financial relationships listed for these individuals have been mitigated.


This course is designed solely to provide the healthcare professional with information to assist in his/her practice and professional development and is not to be considered a diagnostic tool to replace professional advice or treatment. The course serves as a general guide to the healthcare professional, and therefore, cannot be considered as giving legal, nursing, medical, or other professional advice in specific cases. AKH Inc. specifically disclaim responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through participant's misunderstanding of the content.

Disclosure of Unlabeled Use and Investigational Product

This educational activity may include discussion of uses of agents that are investigational and/or unapproved by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Available Credit

  • 1.00 ACPE Pharmacy
  • 1.00 AMA PRA Category 1 Credit
  • 1.00 ANCC
  • 1.00 Participation
Please login or register to take this course.

Required Hardware/software

A computer with an internet connection

Internet Browser: Internet Explorer 7.x or higher, Firefox 4.x or higher, Safari 2.x or higher, or any other W3C standards compliant browser

Other additional software may be required such as PowerPoint or Adobe Acrobat Reader.