A Closer Look: CDKL5 Deficiency Disorder & Rescue Treatment

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a rare developmental epileptic encephalopathy caused by mutations in the CDLK5 gene. The CDKL5 gene provides instructions for making proteins essential for normal brain and neuron development. When there is a deficiency disorder, a hallmark symptom is seizures beginning at approximately 3 months of life. The occurrence of seizures is unpredictable and often dangerous, increasing the risk of injury, hospitalization, and mortality, and adversely affecting a patient’s mental health, often resulting in anxiety, depression, or cognitive impairment. Both targeted treatments and rescues anti-epileptics are used to mitigate this chronic condition and improve the patient’s quality of life. This session will outline an overview of CDLK5 deficiency, with an emphasis on clinical presentation, challenges related to frequent seizures, differential diagnosis, and therapeutics behind the treatment landscape.

This session is supported by an educational grant from Neurelis.

This activity is provided by Global Education Group

Learning Objectives

After completing this activity, the participant should be better able to:

  • Describe the incidence rate, etiology, and clinical presentation of CDKL5 deficiency
  • Discuss the challenges imposed on the patient’s quality of life for patients who experience frequent seizure
  • Review the efficacy and safety profiles of medications for seizures associated with CDKL5 deficiency disorder
  • Summarize available rescue treatment for patients who suffer from frequent seizures
Course summary
Available credit: 
  • 0.25 ACCME (All Other)
  • 0.25 ACCME (MD/DO Only)
  • 0.25 ACPE Pharmacy
  • 0.25 ANCC
Course opens: 
Course expires: 
Raj Rajaraman, MD, MS
Sabreet Kaur Dhillon, PharmD

Physician Accreditation Statement

Global Education Group is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Physician Credit Designation

Global Education Group designates this enduring for a maximum of .25 AMA PRA Category 1 Credit ™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nursing Continuing Education

Global Education Group is accredited with distinction as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation

This educational activity for .25 contact hours is provided by Global Education Group. Nurses should claim only the credit commensurate with the extent of their participation in the activity.

Pharmacist Accreditation Statement

Global Education Group is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

Credit Designation

Global Education Group designates this continuing education activity for .25 contact hour(s) (0.1 CEUs) of the Accreditation Council for Pharmacy Education. (Universal Activity Number - 0530-0000-22-362-H01-P)

This is a knowledge-based activity.

Term Offering

This activity was released on 12/15/2022 and is valid for one year. Requests for credit must be made no later than 12/15/2023.

Global Contact Information

For information about the accreditation of this program, please contact Global at 303-395-1782 or cme@globaleducationgroup.com.

Instructions to Receive Credit

In order to receive credit for this activity, the participant must complete and pass the posttest with a score of at least 70% and complete the evaluation/application for credit. Certificates will then be available for download. Pharmacists: Credit will be awarded via CPE Monitor 60 days post the enduring meeting

Fee & Refund/Cancellation Policy

There is no fee for this educational activity.

Disclosure of Conflicts of Interest

Global Education Group (Global) adheres to the policies and guidelines, including the Standards for Integrity and Independence in Accredited CE, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous. All persons in a position to control the content of an accredited continuing education program provided by Global are required to disclose all financial relationships with any ineligible company within the past 24 months to Global. All financial relationships reported are identified as relevant and mitigated by Global in accordance with the Standards for Integrity and Independence in Accredited CE in advance of delivery of the activity to learners. The content of this activity was vetted by Global to assure objectivity and that the activity is free of commercial bias.

The planners and managers at Global Education Group have no relevant financial relationships to disclose.

All relevant financial relationships have been mitigated.

The faculty have the following relevant financial relationships with ineligible companies:

Name of Faculty or Presenter
Reported Financial Relationship

Raj Rajaraman

Consulting Fee: Zogenix Pharmaceauticals                        

Contracted Research: Zogenix Pharmaceuticals, Marinus Pharmaceauticals

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group (Global) does not recommend the use of any agent outside of the labeled indications. 

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Available Credit

  • 0.25 ACCME (All Other)
  • 0.25 ACCME (MD/DO Only)
  • 0.25 ACPE Pharmacy
  • 0.25 ANCC
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