This session, presented by a neurologist and a psychiatrist, demonstrates how migraine can present with varying degrees of complexity. While the underlying condition may generate various subtypes requiring the expertise of a neurologist, the psychiatrist may need to address barriers to optimal outcomes like comorbid major depression, overuse of analgesics, lack of effective coping strategies, and how to manage the difficult patient. Case studies will highlight the different approaches each specialist adopts in managing migraineurs who face additional challenges imposed by comorbid conditions.