Imagine being a patient walking through the OTC analgesic aisle in a pharmacy, past the 500 boxes of acetaminophen, to the hundreds of topical pain medication options. Imagine being a healthcare professional recommending topical pain medications without knowing that there's a dozen versions of the product. Scary? Concerning? Unsettling? Just how do we as healthcare professionals navigate the plethora of topical pain medication options? During this discussion, we’ll clear the fog on which ingredients do what, and what ingredients are in what, along with explanations of how to explain respective administrations to patients. Who knows, maybe the next time you're in pain, you'll be able to figure out what you'll need, too!