Patients with opioid use disorder or a history of opioid use disorder who undergo planned or emergent surgical procedures have difficult and often complex perioperative pain. In this course, two clinical pharmacist specialists in pain management and a board certified addiction medicine physician, who currently practice on addiction consult teams at large academic medical centers, will dive into the clinical considerations and evidence based therapeutic strategies for treating acute pain in patients with opioid use disorder. Perioperative planning and pharmacologic approaches will be described and discussed via a series of complex clinical patient cases presented throughout the course. The considerations for treating acute pain in a patient taking a medication for opioid use disorder including methadone and buprenorphine-naloxone will be discussed, in addition to factors to anticipate in the transitions of care planning in this vulnerable population. This course will help multidisciplinary team members recognize the importance of appropriately treating pain in patients with opioid use disorder and learn select pharmacologic and nonpharmacologic approaches to consider in the perioperative setting.