Effective clinical management of pain requires an understanding of the underlying mechanisms responsible for its generation. A skillful approach based upon better knowledge concerning the anatomical structures, pathways and events that result in pain is more likely to lead to effective clinical management of pain. This course takes also takes into account that being able to explain the complex process of pain transmission in a less complex manner can significantly help providers to recognize clinical outcomes and to better able the patient and other care givers to play a greater role in in the treatment of painful disorders. The discussion will also include an introductory reference to overview of medication classes and non-pharmacologic options typically considered for pain and the pathways they affect. In addition, there are numerous clinical pearls to demonstrate the value role of pain education in patient care. e pathways they affect.