Comprehensive pain assessment allows practitioners to determine the most likely pathogenesis of pain, which helps guide selection of appropriate therapy. This is a two-part presentation. In Part 1, Pain Assessment, participants will discuss the importance of pain assessment, learn to assess a patient’s pain complaint using the “PQRSTU” approach, perform pain assessments using single- and multidimensional pain assessment tools, and identify common barriers to pain assessment and strategies to mitigate them. In Part 2, Pathogenesis of Pain, participants will learn about the various components of pain signaling (including the role of A-delta and C-fibers), define terms such as hyperalgesia, allodynia, and wind up, and differentiate between visceral, somatic, and neuropathic pain.