Patients with a serious or advanced illness often need to be switched (or rotated) from one opioid to a different opioid, or between dosage formulations or routes of administration. Participants in this presentation will learn about the concept of equianalgesia, and how to switch from one dosage formulation or route of administration to a different one using the same opioid, and how to switch entirely from one opioid to a different opioid, using a variety of dosage formulations and routes of administration. Timing of switches, dosing analgesics for breakthrough pain, and monitoring suggestions will also be addressed.