Controversy exists about whether or not significant progress has taken place with respect to pain and its management. Unfortunately, few would deny that racial bias persists in pain assessment and treatment. In some cases, this is the result of false beliefs about differences between white people and people of color, but in many other cases, discrimination may be rooted in stereotyping and prejudice. This session will focus on the intersection of racism, stereotyping, and another important factor that may contribute to unequitable, unethical, and unbalanced delivery of pain care: social determinants of health. Specific detail will be paid to recent research and publications identifying persistent and concerning discrepancies based on these and related factors, not only in the adult patient population, but also in the delivery of pediatric pain care. Sickle cell disease related pain and common barriers to its effective treatment will be discussed in depth. Recommendations from the American Medical Association and the U.S. Department of Health and Human Services, among others, will be discussed, with the intention of providing concrete steps that can be collectively taken to address these and related issues in pain management.