Is there value to skeletal muscle relaxants? In this session, presenters will explore why pain related to muscle spasm occurs, the role of skeletal muscle relaxants in symptom control, and special considerations in management of these medications. Presenters will explore clinical scenarios that present unique challenges to a palliative care team, including cancer related pain, spasticity due to neurologic conditions, and chronic nonmalignant pain. Special populations at high risk for adverse events, including the elderly with comorbid addiction, will be highlighted. Clinical cases will demonstrate the potential benefit from skeletal muscle relaxants. We will also identify gaps in knowledge and discuss clinical situations where skeletal muscle relaxants have shown to be ineffective; evidence for their efficacy continues to be limited. There is potential value for muscle relaxants for improving non-opioid management. After this session participants will feel more confident evaluating the appropriateness of patients taking muscle relaxants as well as those who maybe good candidates to begin a muscle relaxant.