Migraine is a complex disorder of the nervous system that is recurrent and causes significant disability. In fact, it is the second most common cause of disability worldwide. Migraine attacks can occur unpredictably and are a major cause of missed time from work and other activities. The impact of migraine is staggering, affecting about 40 million Americans. Women have a significantly increased risk, and almost 1 in 5 are affected. Because migraine is often genetically transmitted, many families are impacted. This course will look at current diagnosis and secondary headache causes, cover what migraine is, and look at the common evolution of a migraine attack. Also to be discussed: the current classifications of migraine and what they mean in terms of disability and treatment, and the evolution of the understanding of migraine pathology and how it has introduced newer interventions for this patient population. Older theories will be covered, as well as what is understood today and the importance of CGRP, the risk factors for chronification of migraine, and how to take a headache history.