Everyone is familiar with the process of prescribing medications, which includes carefully consideration of patient- and drug-related variables. However, drug therapy is not meant to be continued forever, but adjusted or discontinued as the patient’s clinical situation changes. Participants in this presentation will learn about the process of “deprescribing” – stopping medications when they no longer meet the patient’s goals of care, they are medically futile, or the burden exceeds the benefit of drug therapy. Learners will also gain valuable pointers on how to have those conversations with patients, families and other healthcare providers in the process of deprescribing.