Methadone is a strong opioid used to treat moderate to severe pain in patients with serious or advanced illness. Methadone is pharmacologically different from many opioids, and it is essential that providers understand the pharmacodynamic and pharmacokinetic differences between methadone and more customary opioids. This presentation will cover those pharmacologic differences, and address methadone dosing in opioid-naïve and opioid-tolerant patients. Participants will learn how to monitor and titrate methadone therapy, and manage adverse effects