Methadone, buprenorphine, and naltrexone are complex medications with a multitude of uses. Perhaps most commonly known for their role in the treatment of opioid use disorder, these medications at low doses have unique utility in pain management. This session will focus on the use of low dose methadone, naltrexone, and microdosing of buprenorphine in pain management. Three experienced clinicians will present rationale, evidence, and best practices on the use of these low-dose strategies.