This session will highlight the biopsychosocial model of pain and current concepts in pain science with an emphasis on neurophysiological and cognitive contributions to the pain experience. Included will be adverse childhood events and their role in stress response; ascending and descending pain pathways; the brain’s role in surveillance and prediction in the pain experience; and framing and cognitive restructuring. The role of neuromodulation—including radiofrequency, cryoanalgesia, and peripheral nerve stimulation—and specific indications for the treatment of osteoarthritis pain will be discussed. The session will combine a traditional lecture presentation with an innovative and engaging video curated for and specific to the presentation with opportunities for access to additional online/app-based virtual learning modules.