This presentation will cover some of the most recent evidence in the treatment of lumbar degenerative disc disease and low back pain with recently developed biological products. The robust evolving evidence will provide clinicians with new methods to treat lumbar degenerative disc disease and slow the progression of disease in such patients while avoiding more involved and potentially irreversible interventions. The early data are promising for the advent of a new path to change the standard of care algorithm in patients with chronic low back pain due to mild to moderate lumbar degenerative disc disease.