With cutbacks on opioids, patients may resort to the pharmacy aisles for pain relief. What’s on those shelves? A whole lot of good, bad, and everything in between. Updated from its original debut at PAINWeek 2019, this session will introduce new kids on the block (or the OTC aisle) and provide an overview of everything from “rapid release” oral formulations to topical products. Efficacy and safety considerations as well as pharmacokinetic information, dosing, and important administration instructions will be discussed. In addition, the place of various nonprescription analgesics in the management of common painful conditions according to new guidelines will be highlighted. By the end of this presentation, participants will be prepared to revisit the OTC analgesic aisle and provide patients with product selection guidance and counseling. This is your place for OTC pearls and perils!