Empowering patients to feel confident in managing their pain with new tools is an important goal for healthcare systems amidst the opioid epidemic and rising incidence of overdoses and deaths since the start of the COVID-19 pandemic. To promote the use of alternatives to opioids, the Pain Assessment and Management Initiative (PAMI) at the University of Florida College of Medicine – Jacksonville developed a pain discharge toolkit and carts for resource access in the ED and hospital settings. Each patient toolkit is tailored to patient need, pain type, and comorbidities based on provider or staff assessment or pain coach consultation. This initiative required navigation of legal and regulatory compliance issues, product selection and accompanying educational content, vendor negotiations, and feedback from multidisciplinary healthcare providers to bring the idea to fruition. This presentation will cover lessons learned and best practices regarding the development of an integrative patient pain toolkit for use in the hospital or at discharge to promote the use of alternatives to opioids.