Chemotherapy induced peripheral neuropathy (CIPN) is a common, painful adverse effect that can significantly reduce quality of life and may compromise cancer treatment through necessary dose reductions or therapy cessation. To address neuropathic pain in patients actively receiving chemotherapy and in cancer survivors, pain clinicians should be able to recognize the risk factors, symptoms, and the natural history of CIPN. The prevention and treatment of CIPN is challenging due to limited and often inconsistent evidence. This session will present available information on the pharmacotherapy for prevention and treatment of CIPN and provide a guide for managing acute and chronic pain due to chemotherapy induced neurotoxicity.