Difficulty with medication adherence is common in bipolar disorder and results in significant disability and suffering.  There are many potential barriers to medication adherence.  These include external factors such as complex medication regimens, side effects, and issues with access to care, as well as patient specific factors such as sociodemographic issues, maladaptive beliefs about the illness, and the severity and nature of an individual’s bipolar symptoms. This session will provide an overview of these barriers and practical strategies for addressing some of them in clinical practice, with a focus on crafting an effective and tolerable medication regimen for our patients. In particular, the use of long acting injectable (LAI) treatments to enhance medication adherence in bipolar disorder will be explored.